The Sequoia has standard Active Headrests, which use a specially designed headrest to protect the driver and front passenger from whiplash. During a rear-end collision, the Active Headrests system moves the headrests forward to prevent neck and spine injuries. The MDX doesn’t offer a whiplash protection system.
When descending a steep, off-road slope, the Sequoia 4x4’s optional Downhill Assist Control allows you to creep down safely. The MDX doesn’t offer Downhill Assist Control.
Both the Sequoia and the MDX have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and available four-wheel drive.
The Toyota Sequoia weighs 832 to 1914 pounds more than the Acura MDX. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

